Article

Improving the specificity of adenine base editor using high-fidelity Cas9

2019-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Adenine base editor (ABE) mediates the conversion of A to G in genomic DNA. In human, approximately 47.8% of known pathogenic SNPs can be corrected by A to G conversion, indicating that ABE have tremendous potential in gene therapy. However, the off-target activity of ABE limits its clinical application. ABE off-target activity in DNA is depended on the bonding of Streptococcus pyogenes Cas9 (S...

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Literature Corpus work: 258bf9b8-8281-5bf2-919c-ed1f35af56a3
DOI: 10.1101/712109

Open publication

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