Article

SynLethDB 2.0: A web-based knowledge graph database on synthetic lethality for novel anticancer drug discovery

2021-12-28

Abstract excerpt

Two genes are synthetic lethal if mutations in both genes result in impaired cell viability, while mutation of either gene does not affect the cell survival. The potential usage of synthetic lethality (SL) in anticancer therapeutics has attracted many researchers to identify synthetic lethal gene pairs. To include newly identified SLs and more related knowledge, we present a new version of the SynLethDB database t...

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Literature Corpus work: 25670c27-da07-5cfc-8574-d6d20a47d875
DOI: 10.1101/2021.12.28.474346

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