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Article

SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets.

Nucleic acids research - 4 Jan 2016

Guo Jing, Liu Hui, Zheng Jie

Abstract excerpt

Synthetic lethality (SL) is a type of genetic interaction between two genes such that simultaneous perturbations of the two genes result in cell death or a dramatic decrease of cell viability, while a perturbation of either gene alone is not lethal. SL reflects the biologically endogenous difference between cancer cells and normal cells, and thus the inhibition of SL partners of genes with cancer-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26516187
DOI: 10.1093/nar/gkv1108
PMCID: PMC4702809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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