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Article

Human synthetic lethal inference as potential anti-cancer target gene detection.

BMC systems biology - 16 Dec 2009

Conde-Pueyo Nuria, Munteanu Andreea, Solé Ricard V, Rodríguez-Caso Carlos

Abstract excerpt

BACKGROUND: Two genes are called synthetic lethal (SL) if mutation of either alone is not lethal, but mutation of both leads to death or a significant decrease in organism's fitness. The detection of SL gene pairs constitutes a promising alternative for anti-cancer therapy. As cancer cells exhibi...

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Identifiers

PMID: 20015360
DOI: 10.1186/1752-0509-3-116
PMCID: PMC2804737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20015360-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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