Article

Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia

2020-05-22

Abstract excerpt

Most genes associated with Acute Myeloid Leukemia (AML) are mutated in less than 10% of patients, suggesting alternative mechanisms for gene disruption contribute to this disease. Here we find a set of splicing events that disrupt the expression of a subset of AML-associated genes, including EZH2 and ZRSR2, independent of known somatic mutations. Most strikingly, in at least one cohort, aberrant splicing triples t...

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Literature Corpus work: 25623656-e5dd-5a2f-be71-649171c3d3fe
DOI: 10.1101/2020.05.21.107557

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