Article
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
The New England journal of medicine - 30 May 2013
Ley Timothy J, Miller Christopher, Ding Li, Raphael Benjamin J, Mungall Andrew J, Robertson A Gordon, Hoadley Katherine, Triche Timothy J, Laird Peter W, Baty Jack D, Fulton Lucinda L, Fulton Robert, Heath Sharon E, Kalicki-Veizer Joelle, Kandoth Cyriac, Klco Jeffery M, Koboldt Daniel C, Kanchi Krishna-Latha, Kulkarni Shashikant, Lamprecht Tamara L, Larson David E, Lin Ling, Lu Charles, McLellan Michael D, McMichael Joshua F, Payton Jacqueline, Schmidt Heather, Spencer David H, Tomasson Michael H, Wallis John W, Wartman Lukas D, Watson Mark A, Welch John, Wendl Michael C, Ally Adrian, Balasundaram Miruna, Birol Inanc, Butterfield Yaron, Chiu Readman, Chu Andy, Chuah Eric, Chun Hye-Jung, Corbett Richard, Dhalla Noreen, Guin Ranabir, He An, Hirst Carrie, Hirst Martin, Holt Robert A, Jones Steven, Karsan Aly, Lee Darlene, Li Haiyan I, Marra Marco A, Mayo Michael, Moore Richard A, Mungall Karen, Parker Jeremy, Pleasance Erin, Plettner Patrick, Schein Jacquie, Stoll Dominik, Swanson Lucas, Tam Angela, Thiessen Nina, Varhol Richard, Wye Natasja, Zhao Yongjun, Gabriel Stacey, Getz Gad, Sougnez Carrie, Zou Lihua, Leiserson Mark D M, Vandin Fabio, Wu Hsin-Ta, Applebaum Frederick, Baylin Stephen B, Akbani Rehan, Broom Bradley M, Chen Ken, Motter Thomas C, Nguyen Khanh, Weinstein John N, Zhang Nianziang, Ferguson Martin L, Adams Christopher, Black Aaron, Bowen Jay, Gastier-Foster Julie, Grossman Thomas, Lichtenberg Tara, Wise Lisa, Davidsen Tanja, Demchok John A, Shaw Kenna R Mills, Sheth Margi, Sofia Heidi J, Yang Liming, Downing James R, Eley Greg
Abstract excerpt
BACKGROUND: Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear. METHODS: We analyzed the genomes of 200 clinically annotated adult cases of de novo AML, using either whole-genome sequencing (50 cases) or whole-exome sequencing (150 cases), along with RNA and microRNA...
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