Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing.

doi:10.1182/blood-2011-12-401471

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing.

Blood - 1 Nov 2012

Dolnik Anna, Engelmann Julia C, Scharfenberger-Schmeer Maren, Mauch Julian, Kelkenberg-Schade Sabine, Haldemann Berit, Fries Tamara, Krönke Jan, Kühn Michael W M, Paschka Peter, Kayser Sabine, Wolf Stephan, Gaidzik Verena I, Schlenk Richard F, Rücker Frank G, Döhner Hartmut, Lottaz Claudio, Döhner Konstanze, Bullinger Lars

Abstract excerpt

Acute myeloid leukemia (AML) is characterized by molecular heterogeneity. As commonly altered genomic regions point to candidate genes involved in leukemogenesis, we used microarray-based comparative genomic hybridization and single nucleotide polymorphism profiling data of 391 AML cases to further narrow down genomic regions of interest. Targeted resequencing of 1000 genes located in the critical regions was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comparative Genomic Hybridization

Share to RAD21 gene

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Oligonucleotide Array Sequence Analysis

Share to Polymorphism, Single Nucleotide

Share to RNA Splicing

Source

Open in PubMed

Identifiers

PMID: 22976956
DOI: 10.1182/blood-2011-12-401471

Genes

CTCF
DNMT1
NSD1
RAD21
SFPQ
TET1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing.PMID 22976956Read ↗

Unveiling splicing disruptions due to common somatic variants in acute myeloid leukemia.Semantic proximity Read ↗

A Genome-Wide Aberrant RNA Splicing in Patients with Acute Myeloid Leukemia Identifies Novel Potential Disease Markers and Therapeutic TargetsSemantic proximity Read ↗

Landscape of Tumor Suppressor Mutations in Acute Myeloid LeukemiaSemantic proximity Read ↗

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.Semantic proximity Read ↗

Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations.Semantic proximity Read ↗

Prognostic alternative mRNA splicing signatures and associated splicing factors in acute myeloid leukemiaSemantic proximity Read ↗

The evolving molecular genetic landscape in acute myeloid leukaemia.Semantic proximity Read ↗

The Epigenetic Landscape of Acute Myeloid LeukemiaSemantic proximity Read ↗

The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome.Semantic proximity Read ↗

The Role of Somatic Mutations in Acute Myeloid Leukemia Pathogenesis.Semantic proximity Read ↗

Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemiaSemantic proximity Read ↗

The genomic and epigenomic landscapes of AML.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.