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Article

Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia.

Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2021

Rivera Osvaldo D, Mallory Michael J, Quesnel-Vallières Mathieu, Chatrikhi Rakesh, Schultz David C, Carroll Martin, Barash Yoseph, Cherry Sara, Lynch Kristen W

Abstract excerpt

Most genes associated with acute myeloid leukemia (AML) are mutated in less than 10% of patients, suggesting that alternative mechanisms of gene disruption contribute to this disease. Here, we find a set of splicing events that alter the expression of a subset of AML-associated genes independent of known somatic mutations. In particular, aberrant splicing triples the number of patients with reduced functional...

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Identifiers

PMID: 33876749
DOI: 10.1073/pnas.2014967118
PMCID: PMC8054020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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