Article

TRPV4 calcium-permeable channel contributes to valve stiffening in aortic stenosis

2024-11-12

Abstract excerpt

Aortic valve stenosis (AVS) is a progressive disease marked by fibrosis, inflammation, calcification, and stiffening of the aortic valve leaflets, leading to disrupted blood flow and left ventricular pressure overload. AVS can result in heart failure and death within 2 to 5 years if left untreated, highlighting its high mortality rate. Understanding the molecular mechanisms of AVS is essential for developing nonin...

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Literature Corpus work: b54a1f96-8636-5a39-a663-9de96fe7bb10
DOI: 10.1101/2024.11.07.622108

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