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Article

The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to-Mesenchymal Transition of Aortic Valve Endothelial Cells.

Cardiovascular engineering and technology - 1 Jun 2018

Zhong Aileen, Mirzaei Zahra, Simmons Craig A

Abstract excerpt

Valve stiffening is a hallmark of aortic valve stenosis caused by excess extracellular matrix accumulation by myofibroblasts. We aimed to elucidate whether matrix stiffness regulates endothelial-to-mesenchymal transition (EndMT) of adult valvular endothelial cells (VECs) to myofibroblasts as a mechanism to further promote valve fibrosis. In addition, we specifically examined the role of the Wnt/β-catenin...

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Identifiers

PMID: 29761409
DOI: 10.1007/s13239-018-0363-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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