Article

Human-specific <i>NOTCH</i> -like genes in a region linked to neurodevelopmental disorders affect cortical neurogenesis

2017-11-17

Abstract excerpt

<h4>Summary</h4> Genetic changes causing dramatic brain size expansion in human evolution have remained elusive. Notch signaling is essential for radial glia stem cell proliferation and a determinant of neuronal number in the mammalian cortex. We find three paralogs of human-specific NOTCH2NL are highly expressed in radial glia cells. Functional analysis reveals different alleles of NOTCH2NL have varying potencie...

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Literature Corpus work: 2538ee68-c010-59af-a517-4cdae4db71a2
DOI: 10.1101/221226

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