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Article

Duplicate, diversify, repeat: The evolution of NOTCH2NL.

Cell genomics - 10 Jun 2026

Egyes Nachshon, Gokhman David

Abstract excerpt

Segmental duplications are key drivers of evolutionary innovation but are also particularly challenging to study. In this issue, Real et al. resolve the genetic diversity, structural history, and regulatory landscape of the human-specific NOTCH2NL gene family, a likely contributor to human cortical brain expansion.

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Topics

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Share to Evolution, Molecular
Share to Gene Duplication
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to Nerve Tissue Proteins

Share to Receptor, Notch2

Source

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Identifiers

PMID: 42269590
DOI: 10.1016/j.xgen.2026.101274
PMCID: PMC13261643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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