A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling

Abstract excerpt

Heart failure (HF) is characterized by severely reduced cardiac function and tissue remodeling, driven by complex multicellular regulatory processes. Extensive studies have generated molecular profiles at both bulk and single-cell levels; however, systematic integration that describes tissue-wide changes as a function of cell type coordination remains challenging. This disconnect hampers our understanding of the c...

Topics

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• Atherosclerosis and Cardiovascular Diseases
• CAR-T cell therapy research
• Cardiac Fibrosis and Remodeling
• Cardiovascular Function and Risk Factors
• Congenital heart defects research
• IL-33, ST2, and ILC Pathways
• Peptidase Inhibition and Analysis
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

e3217e38-4076-5e6a-896a-318ebaad34ad

DOI

10.1101/2024.11.04.621815