Article

Genetic effects of sequence-conserved enhancer-like elements on human complex traits

2022-08-21

Abstract excerpt

Non-coding sequences that are evolutionarily conserved and bio-chemically active offer clues to mechanistic interpretations of human genome-wide association studies (GWAS). However, their genetic effects have not been systematically examined across a wide range of human tissues and traits. Here we develop a simple method to identify functional elements exhibiting high levels of human-mouse sequence conservation an...

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Literature Corpus work: 628007b7-b792-5a52-a5bf-9e69935cf7b2
DOI: 10.1101/2022.08.19.504589

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