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Cell Cycle Arrest and Cytotoxic Effects of SAHA and RG7388 Mediated through p21<sup>WAF1/CIP1</sup> and p27<sup>KIP1 </sup>in Cancer Cells

2018-10-07

Abstract excerpt

Alterations in gene expressions are often due to epigenetic modifications that can lead to significant influence on cancer development, growth, and progression. The main epigenetic modifications observed in human are methylation and acetylation. In this regard, the HDAC inhibitors (HDACi) such as SAHA (Vorinostat), which can exert epigenetic alterations through impacting the acetylation status of histones, are in...

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Literature Corpus work
24f6bfa7-83f8-5787-9690-09a2e656870e
DOI
10.20944/preprints201810.0121.v1
Open publication

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Cell Cycle Arrest and Cytotoxic Effects of SAHA and RG7388 Mediated through p21<sup>WAF1/CIP1</sup> and p27<sup>KIP1 </sup>in Cancer CellsDOI 10.20944/preprints201810.0121.v1
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