Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell Death

Abstract excerpt

Named as the guardian of the genome, p53 is a tumor suppressor that regulates cell function, often through many different mechanisms such as DNA repair, apoptosis, cell cycle arrest, senescence, metabolism, and autophagy. One of the genes that p53 activates is MDM2, which forms a negative feedback loop since MDM2 induces the degradation of p53. When p53 activity is inhibited, damaged cells do not undergo cell...

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• Cancer-related Molecular Pathways
• Epigenetics and DNA Methylation
• Ubiquitin and proteasome pathways