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Cell cycle regulation and anticancer drug discovery

1 Jan 2017

Abstract excerpt

Cellular growth, development, and differentiation are tightly controlled by a conserved biological mechanism: the cell cycle. This cycle is primarily regulated by cyclin-dependent kinase (CDK)-cyclin complexes, checkpoint kinases, and CDK inhibitors. Deregulation of the cell cycle is a hallmark of the transformation of normal cells into tumor cells. Given its importance in tumorigenesis, several cell cycle...

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PMID: 29372101
DOI: 10.20892/j.issn.2095-3941.2017.0033

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