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HDAC Inhibitor Vorinostat and BET Inhibitor Plx51107 Epigenetic Agents’ Combined Treatments Exert a Therapeutic Approach Upon Acute Myeloid Leukemia Cell Model

2022-09-07

Abstract excerpt

<title>Abstract</title> The process of cancer initiation and development is regulated via the transcriptional expression of cells going under genomic and epigenetic changes. Targeting epigenetic "readers", i.e. bromodomains (BRD) and post-translational modifications of nucleosomal histone proteins regulate gene expression in both cancerous and healthy cells. In this study, the new epigenetic agent BRD inhibito...

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Literature Corpus work: 42becd5a-4c04-5433-9a56-6cee75b79acd
DOI: 10.21203/rs.3.rs-1979303/v1

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