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Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

12 Oct 2021

Abstract excerpt

BACKGROUND: SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. Hence, SAMHD1 inhibitors are promising candidates for the sensitisation of leukaemia cells to nucleoside analogue-based therapy. Here, we investigated the effects of the cytosine...

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PMID: 34641952
DOI: 10.1186/s13046-021-02093-4

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