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SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

2020-02-17

Abstract excerpt

<h4>Summary</h4> The anti-leukaemia agent forodesine causes cytotoxic overload of intracellular deoxyguanosine triphosphate (dGTP) but is efficacious only in a subset of patients. We report that SAMHD1, a phosphohydrolase degrading deoxyribonucleoside triphosphates (dNTPs), protected cells against the effects of dNTP imbalances. SAMHD1-deficient cells induced intrinsic apoptosis upon provision of deoxyribonucleos...

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Identifiers and source

Literature Corpus work
b85f005e-0667-58e2-8d2c-26b4e2959b34
DOI
10.1101/2020.02.17.951517
Open publication

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