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Article

With me or against me: Tumor suppressor and drug resistance activities of SAMHD1.

Experimental hematology - 1 Aug 2017

Herold Nikolas, Rudd Sean G, Sanjiv Kumar, Kutzner Juliane, Myrberg Ida Hed, Paulin Cynthia B J, Olsen Thale Kristin, Helleday Thomas, Henter Jan-Inge, Schaller Torsten

Abstract excerpt

Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis. Mutations in SAMHD1 have been associated with the hyperinflammatory disease Aicardi-Goutières syndrome (AGS). SAMHD1 also limits cells' permissiveness to infection with...

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Source

Identifiers

PMID: 28502830
DOI: 10.1016/j.exphem.2017.05.001

Genes

SAMHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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