Article

Interleukin-17A causes osteoarthritis-like transcriptional changes in human osteoarthritis-derived chondrocytes and synovial fibroblasts <i>in vitro</i>

2021-03-07

Abstract excerpt

Increased interleukin (IL)-17A has been identified in joints affected by osteoarthritis (OA), but it is unclear how IL-17A, and its family members IL-17AF and IL-17F, can contribute to human OA pathophysiology. Therefore, we aimed to evaluate the gene expression and signalling pathway activation effects of the different IL-17 family members in fibroblasts derived from cartilage and synovium of patients with end-st...

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Literature Corpus work: 24de34b3-d086-56fb-97e4-17a1fae50441
DOI: 10.1101/2021.03.05.434099

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