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Article

IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes.

Annals of the rheumatic diseases - 1 Aug 2012

Hot Arnaud, Zrioual Saloua, Lenief Vanina, Miossec Pierre

Abstract excerpt

OBJECTIVES: To examine the effect of interleukin-17 (IL-17) on rheumatoid arthritis (RA) synoviocyte migration and invasiveness. METHODS: IL-17A and tumour necrosis factor α (TNFα)-induced messenger RNA expression in RA synoviocytes was analysed using Affymetrix U133A microarrays. The capacity of IL-17 alone or in combination with TNFα to induce synoviocyte migration and invasion was tested using Boyden and...

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Source

Identifiers

PMID: 22532631
DOI: 10.1136/annrheumdis-2011-200867

Genes

CXCR4
MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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