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Article

Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis

4 May 2022

Abstract excerpt

Damaged hyaline cartilage has no capacity for self-healing, making osteoarthritis (OA) "difficult-to-treat". Cartilage destruction is central to OA patho-etiology and is mediated by matrix degrading enzymes. Here we report decreased expression of miR-17 in osteoarthritic chondrocytes and its deficiency contributes to OA progression. Supplementation of exogenous miR-17 or its endogenous induction by growth...

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PMID: 35508470
DOI: 10.1038/s41467-022-30119-8

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