Article

Evolving Notch polyQ tracts reveal possible solenoid interference elements

2016-10-03

Abstract excerpt

<h4>ABSTRACT</h4> Polyglutamine (polyQ) tracts in regulatory proteins are extremely polymorphic. As functional elements under selection for length, triplet repeats are prone to DNA replication slippage and indel mutations. Many polyQ tracts are also embedded within intrinsically disordered domains, which are less constrained, fast evolving, and difficult to characterize. To identify structural principles underlyi...

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Literature Corpus work: 24c4b5d3-6538-59b8-aa54-1fb559453828
DOI: 10.1101/079038

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