Article
The Nature, Extent, and Consequences of Genetic Variation in the opa Repeats of Notch in Drosophila.
G3 (Bethesda, Md.) - 10 Sept 2015
Rice Clinton, Beekman Danielle, Liu Liping, Erives Albert
Abstract excerpt
Polyglutamine (pQ) tracts are abundant in proteins co-interacting on DNA. The lengths of these pQ tracts can modulate their interaction strengths. However, pQ tracts >40 residues are pathologically prone to amyloidogenic self-assembly. Here, we assess the extent and consequences of variation in the pQ-encoding opa repeats of Notch in Drosophila melanogaster. We use Sanger sequencing to genotype opa sequences...
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