Article

The features of polyglutamine regions depend on their evolutionary stability

2020-05-06

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Polyglutamine regions (polyQ) are one of the most studied and prevalent homorepeats in eukaryotes. They have a particular length-dependent codon usage, which relates to a characteristic CAG-slippage mechanism. Pathologically expanded tracts of polyQ are known to form aggregates and are involved in the development of several human neurodegenerative diseases. The...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6a55cfb-d22a-5def-a163-3ccd0a6c05e4
DOI: 10.21203/rs.3.rs-15440/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The features of polyglutamine regions depend on their evolutionary stabilityDOI 10.21203/rs.3.rs-15440/v2Read

The structural plasticity of polyglutamine repeatsSemantic proximity Read

Polyalanine expansions in humanSemantic proximity Read

Evolving Notch polyQ tracts reveal possible solenoid interference elementsSemantic proximity Read

Juvenile Huntington’s Disease and Other PolyQ diseases, Update on Neurodevelopmental Character and Comparative Bioinformatic Review of Transcriptomic DataSemantic proximity Read

Pervasive convergent evolution and extreme phenotypes define chaperone requirements of protein homeostasisSemantic proximity Read

A census of glutamine/asparagine-rich regions: Implications for their conserved function and the prediction of novel prionsSemantic proximity Read

CAG-encoded polyglutamine length polymorphism in the human genomeSemantic proximity Read

Insights into the evolution and domain structure of ataxin-2 proteins across eukaryotesSemantic proximity Read

Juvenile Huntington’s Disease and Other PolyQ Diseases, Update on Neurodevelopmental Character and Comparative Bioinformatic Review of Transcriptomic and Proteomic DataSemantic proximity Read

A universal trend of amino acid gain and loss in protein evolution.Semantic proximity Read

Terminal regions of a protein are a hotspot for low complexity regions and selection.Semantic proximity Read

RCPdb: An evolutionary classification and codon usage database for repeat-containing proteins.Semantic proximity Read