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Theme and variations: evolutionary diversification of the HET-s functional amyloid motif

29 Jul 2015

Abstract excerpt

In mammals and fungi, Nod-like receptors (NLR) activate downstream cell death execution proteins by a prion-like mechanism. In Podospora anserina, the NWD2 NLR activates the HET-S Helo-domain pore-forming protein by converting its prion-forming domain into a characteristic β-solenoid amyloid fold. The amyloid forming region of HET-S/s comprises two repetitions of a 21 amino acid motif. Herein, we systematically...

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PMID: 26219477
DOI: 10.1038/srep12494

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