Article

Protein-protein interaction is a major source of epistasis in genetic interaction networks

2024-11-14

Abstract excerpt

Genetic interaction (GI) and protein-protein interaction (PPI) networks have proved among the most important tools for inference of gene function and genotype-phenotype relationship 1–6 . It remains unclear, however, how these two networks are related to each other. Here we demonstrate that the strengths of epistatic genetic interactions between two genes strongly correlate with the binding free energies of inter...

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Literature Corpus work: 24c36a76-468e-5b44-8dd8-e47975f5c9c2
DOI: 10.1101/2024.11.11.623081

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