Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary plasticity of genetic interaction networks.

Nature genetics - 1 Apr 2008

Tischler Julia, Lehner Ben, Fraser Andrew G

Abstract excerpt

Non-additive genetic interactions contribute to many genetic disorders, but they are extremely difficult to predict. Here we show that genetic interactions identified in yeast, unlike gene functions or protein interactions, are not highly conserved in animals. Genetic interactions are therefore unlikely to represent simple redundancy between genes or pathways, and genetic interactions from yeast do not directly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Genes, Lethal

Share to Protein Interaction Mapping

Share to RNA, Small Interfering

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 18362882
DOI: 10.1038/ng.114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary plasticity of genetic interaction networks.PMID 18362882Read ↗

Genetic interaction networks: toward an understanding of heritability.Semantic proximity Read ↗

Modelling genotype-phenotype relationships and human disease with genetic interaction networks.Semantic proximity Read ↗

Systematic analysis of complex genetic interactions.Semantic proximity Read ↗

Conservation of the genetic interaction network between two yeast speciesSemantic proximity Read ↗

Conserved rules govern genetic interaction degree across species.Semantic proximity Read ↗

A global genetic interaction map of a human cell reveals conserved principles of genetic networksSemantic proximity Read ↗

Predictability of Genetic Interactions from Functional Gene ModulesSemantic proximity Read ↗

Exploring genetic interactions and networks with yeast.Semantic proximity Read ↗

Environmental robustness of the global yeast genetic interaction network.Semantic proximity Read ↗

Protein complexes are central in the yeast genetic landscape.Semantic proximity Read ↗

Organization principles in genetic interaction networks.Semantic proximity Read ↗

Predicting genetic modifier loci using functional gene networks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.