Article

Distinct functions of <i>PBRM1</i> and <i>BAP1</i> reconcile the course of kidney cancer evolution and disease progression

2026-05-03

Abstract excerpt

<h4>SUMMARY</h4> Clear cell renal cell carcinoma (ccRCC) progresses along two predominant evolutionary trajectories, defined by PBRM1 (∼40%) or BAP1 (∼15%) mutations on a VHL -inactivated background. They have distinct patterns of evolutionary tempo and mode, and vastly different clinical outcomes, yet the underlying genotype-specific molecular phenotypic programmes are unknown. We established a patient-derive...

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Literature Corpus work: 24c359a9-24a4-58e6-8df1-07479604b0c6
DOI: 10.64898/2026.04.30.721837

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