BAP1 loss defines a new class of renal cell carcinoma.

doi:10.1038/ng.2323

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Article

BAP1 loss defines a new class of renal cell carcinoma.

Nature genetics - 10 Jun 2012

Peña-Llopis Samuel, Vega-Rubín-de-Celis Silvia, Liao Arnold, Leng Nan, Pavía-Jiménez Andrea, Wang Shanshan, Yamasaki Toshinari, Zhrebker Leah, Sivanand Sharanya, Spence Patrick, Kinch Lisa, Hambuch Tina, Jain Suneer, Lotan Yair, Margulis Vitaly, Sagalowsky Arthur I, Summerour Pia Banerji, Kabbani Wareef, Wong S W Wendy, Grishin Nick, Laurent Marc, Xie Xian-Jin, Haudenschild Christian D, Ross Mark T, Bentley David R, Kapur Payal, Brugarolas James

Abstract excerpt

The molecular pathogenesis of renal cell carcinoma (RCC) is poorly understood. Whole-genome and exome sequencing followed by innovative tumorgraft analyses (to accurately determine mutant allele ratios) identified several putative two-hit tumor suppressor genes, including BAP1. The BAP1 protein, a nuclear deubiquitinase, is inactivated in 15% of clear cell RCCs. BAP1 cofractionates with and binds to HCF-1 in...

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Identifiers

PMID: 22683710
DOI: 10.1038/ng.2323
PMCID: PMC3788680

Genes

BAP1
PBRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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