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Article

The Epigenetics of Renal Cell Tumors: from Biology to Biomarkers

1 Jan 2012

Abstract excerpt

Renal cell tumors (RCT) collectively constitute the third most common type of genitourinary neoplasms, only surpassed by prostate and bladder cancer. They comprise a heterogeneous group of neoplasms with distinctive clinical, morphological, and genetic features. Epigenetic alterations are a hallmark of cancer cells and their role in renal tumorigenesis is starting to emerge. Aberrant DNA methylation, altered...

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PMID: 22666228
DOI: 10.3389/fgene.2012.00094

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