Article

<i>PBRM1</i> loss-of-function mutations and response to immune checkpoint blockade in clear cell renal cell carcinoma

2020-11-04

Abstract excerpt

<h4>ABSTRACT</h4> The biological role of PBRM1 loss-of-function (LOF) mutations mediating response to immune checkpoint blockade (ICB) in clear cell renal cell carcinoma (ccRCC) remains an area of active investigation. A recent study (hereafter, ‘the MSK study’) evaluated this hypothesis in a clinically heterogeneous single institution retrospective ccRCC cohort using targeted sequencing and did not find a univari...

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Literature Corpus work: 4d299f59-6f1f-54e6-87e2-f02e549fb6b0
DOI: 10.1101/2020.10.30.20222356

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