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Article

Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma.

International journal of molecular sciences - 16 Aug 2017

Mehdi Ali, Riazalhosseini Yasser

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC), the most common form of Kidney cancer, is characterized by frequent mutations of the von Hippel-Lindau (VHL) tumor suppressor gene in ~85% of sporadic cases. Loss of pVHL function affects multiple cellular processes, among which the activation of hypoxia inducible factor (HIF) pathway is the best-known function. Constitutive activation of HIF signaling in turn activates...

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Topics

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Share to Carcinoma, Renal Cell
Share to Epigenesis, Genetic
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PBRM1 gene

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Source

Open in PubMed Open full text

Identifiers

PMID: 28812986
DOI: 10.3390/ijms18081774
PMCID: PMC5578163

Genes

VHL
BAP1
PBRM1
SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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