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Article

Bap1 and Pbrm1: Determinants of Tumor Grade and mTOR Activation in VHL-Deficient Mouse Models of Renal Cell Carcinoma.

Cancer discovery - 1 Aug 2017

Leung Janet Y, Kim William Y

Abstract excerpt

<b/> Large genome sequencing efforts have identified frequent mutations in the histone-modifying and chromatin-remodeling genes BAP1 and PBRM1 in clear cell renal cell carcinoma (ccRCC). In this issue of Cancer Discovery, Gu and colleagues model these genetic events in mice and report that dual inactivation of Vhl with either Bap1 or Pbrm1 results in faithful genetically engineered murine models of ccRCC....

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Share to Carcinoma, Renal Cell
Share to Chromatin Assembly and Disassembly
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28765116
DOI: 10.1158/2159-8290.CD-17-0610
PMCID: PMC7549016

Genes

BAP1
PAX8
PBRM1
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Bap1 and Pbrm1: Determinants of Tumor Grade and mTOR Activation in VHL-Deficient Mouse Models of Renal Cell Carcinoma.PMID 28765116Read ↗

Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.Semantic proximity Read ↗

PBRM1 and BAP1 as novel targets for renal cell carcinoma.Semantic proximity Read ↗

Distinct functions of <i>PBRM1</i> and <i>BAP1</i> reconcile the course of kidney cancer evolution and disease progressionSemantic proximity Read ↗

Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL <sup>−/−</sup> clear cell renal carcinomaSemantic proximity Read ↗

BAP1, PBRM1 and SETD2 in clear-cell renal cell carcinoma: molecular diagnostics and possible targets for personalized therapies.Semantic proximity Read ↗

The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

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BAP1-Mutated Clear Cell Renal Cell Carcinoma.Semantic proximity Read ↗

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