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Mutation-specific CAR T cells as precision therapy for IGLV3-21 <sup>R110</sup> expressing high-risk chronic lymphocytic leukemia

2023-10-02

Abstract excerpt

The concept of precision cell therapy targeting tumor-specific mutations is appealing but requires surface-exposed neoepitopes, which is a rarity in cancer. B cell receptors (BCR) of mature lymphoid malignancies are exceptional in that they harbor tumor-specific-stereotyped sequences in the form of point mutations that drive self-engagement of the BCR and autologous signaling. Here, we used a BCR light chain neoep...

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Literature Corpus work
24c164b3-9467-59d8-b756-b6b7eb3d1725
DOI
10.1101/2023.09.29.560075
Open publication

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Mutation-specific CAR T cells as precision therapy for IGLV3-21 <sup>R110</sup> expressing high-risk chronic lymphocytic leukemiaDOI 10.1101/2023.09.29.560075
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