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T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies

26 Jul 2022

Abstract excerpt

Abstract The success of chimeric antigen receptor (CAR) T cells in treating B cell malignancies comes at the price of eradicating normal B cells. Even though T cell malignancies are aggressive and treatment options are limited, similar strategies for T cell malignancies are constrained by the severe immune suppression arising from bystander T cell aplasia. Here, we show the selective killing of malignant T cells...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 35882880
DOI: 10.1038/s41467-022-32092-8

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