Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia.

doi:10.1038/s41467-024-45378-w

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Article

Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia.

Nature communications - 2 Feb 2024

Märkl Florian, Schultheiß Christoph, Ali Murtaza, Chen Shih-Shih, Zintchenko Marina, Egli Lukas, Mietz Juliane, Chijioke Obinna, Paschold Lisa, Spajic Sebastijan, Holtermann Anne, Dörr Janina, Stock Sophia, Zingg Andreas, Läubli Heinz, Piseddu Ignazio, Anz David, Minden Marcus Dühren-von, Zhang Tianjiao, Nerreter Thomas, Hudecek Michael, Minguet Susana, Chiorazzi Nicholas, Kobold Sebastian, Binder Mascha

Abstract excerpt

The concept of precision cell therapy targeting tumor-specific mutations is appealing but requires surface-exposed neoepitopes, which is a rarity in cancer. B cell receptors (BCR) of mature lymphoid malignancies are exceptional in that they harbor tumor-specific-stereotyped sequences in the form of point mutations that drive self-engagement of the BCR and autologous signaling. Here, we use a BCR light chain...

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PMID: 38307904
DOI: 10.1038/s41467-024-45378-w
PMCID: PMC10837166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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