Article

Multi-omics profiling identifies IL-13 signaling as a key mediator in Dupilumab-associated severe corneal injury

2026-03-28

Abstract excerpt

<title>Abstract</title> <p>Objective To explore the epidemiological profile of Dupilumab-associated severe corneal injury (DASCI) using large-scale real-world evidence, and to investigate its underlying molecular mechanisms through integrated single-cell transcriptomic and network analysis. Methods A retrospective pharmacovigilance analysis focusing on Dupilumab was carried out utilizing the U.S. Food and Drug...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 24ab43bb-0cf8-5e6c-9b0a-93bdb2f304c9
DOI: 10.21203/rs.3.rs-9212855/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-omics profiling identifies IL-13 signaling as a key mediator in Dupilumab-associated severe corneal injuryDOI 10.21203/rs.3.rs-9212855/v1Read

Higher Rates of COVID-19 but Less Severe Infections Reported for Patients on Il-4/Il-13 Blocker: A Big Data Analysis of the WHO VigibaseSemantic proximity Read

Application of Tocilizumab in Drug-Induced Liver Injury: Pharmacovigilance Study Using the FAERS Database and the Drug-Gene Interaction Network AnalysisSemantic proximity Read

Dermatomyositis predominates among checkpoint inhibitor-associated inflammatory myositis phenotypes: a pharmacovigilance disproportionality analysis identifies a class-wide signal.Semantic proximity Read

Transcriptional profiling specifies the pathogen-specific human host response to infectious keratitisSemantic proximity Read

Ophthalmic Immune-Related Adverse Events in Cancer Immunotherapy: Tissue-Specific Mechanisms, Clinical Phenotypes, and Consensus-Based Management.Semantic proximity Read

Comprehensive Transcriptome Analysis of Patients With Keratoconus Highlights the Regulation of Immune Responses and Inflammatory ProcessesSemantic proximity Read

Integrated multi-omics analysis combined with clinical validation reveals that HLA-DRB5 and ODAPH are causal risk genes for keratoconus.Semantic proximity Read

Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing dataSemantic proximity Read

Ancestry-associated immune signalling differences in atopic dermatitis and dupilumab treatmentSemantic proximity Read

Pharmacovigilance Insights into Gastrointestinal Adverse Events of JAK Inhibitors: FAERS Signal Detection with Clinical and Pharmacological ImplicationseSemantic proximity Read

Deciphering and verifying cuproptosis-associated hub genes in diabetic foot ulcer by combining single-cell and bulk RNA-sequencingSemantic proximity Read

Identification of the regulatory circuit governing corneal epithelial fate determination and diseaseSemantic proximity Read