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Transcriptional profiling specifies the pathogen-specific human host response to infectious keratitis

10 Jan 2024

Abstract excerpt

Purpose: Corneal infections are a leading cause of visual impairment and blindness worldwide. Here we applied high-resolution transcriptomic profiling to assess the general and pathogen-specific molecular and cellular mechanisms during human corneal infection. Methods: Clinical diagnoses of herpes simplex virus (HSV) (n=5) and bacterial/fungal (n=5) keratitis were confirmed by histology. Healthy corneas (n=7) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38274739
DOI: 10.3389/fcimb.2023.1285676

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