Article

Pharmacovigilance Insights into Gastrointestinal Adverse Events of JAK Inhibitors: FAERS Signal Detection with Clinical and Pharmacological Implicationse

2025-09-12

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Janus-kinase (JAK) inhibitors are increasingly used across surgical practice for immune-mediated disorders, yet their gastrointestinal (GI) safety profiles remain incompletely defined. Upadacitinib (selective JAK-1) has been linked to severe mucosal complications, whereas ruxolitinib (JAK-1/2) appears better tolerated. Robust real-world comparisons are lackin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9eecb040-2789-53d3-83d3-90770b7a14a8
DOI: 10.21203/rs.3.rs-7427805/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pharmacovigilance Insights into Gastrointestinal Adverse Events of JAK Inhibitors: FAERS Signal Detection with Clinical and Pharmacological ImplicationseDOI 10.21203/rs.3.rs-7427805/v1Read

Adverse event analysis and signal detection of calcitonin gene-related peptide inhibitors using the FDA Adverse Event Reporting System databaseSemantic proximity Read

Cross-Database Analysis of Fruquintinib-Associated adverse events: Insights from FAERS and VigiAccess databasesSemantic proximity Read

Infliximab-associated Gastrointestinal Obstruction: A Pharmacovigilance Analysis of the FDA Adverse Event Reporting System (2004-2024)Semantic proximity Read

Adverse reactions associated with the use of ustekinumab in Crohn's disease treatment：an analysis based on the FAERS databaseSemantic proximity Read

Gastrointestinal adverse events associated with Riociguat: A pharmacovigilance study based on FDA adverse event reporting systemSemantic proximity Read

Safety assessment of KRAS (G12C) inhibitors based on the FDA Adverse Event Reporting System (FAERS) database: A real-world pharmacovigilance study.Semantic proximity Read

Class-Wide Disproportionate Reporting of Impaired Gastric Emptying Across Nine Glucagon-Like Peptide-1 Receptor Agonist Products: A Signal-Detection Analysis of the FDA Adverse Event Reporting SystemSemantic proximity Read

A real-world pharmacovigilance study of FDA Adverse Event Reporting System (FAERS) events for OsimertinibSemantic proximity Read

Pharmacovigilance study of BCR-ABL1 tyrosine kinase inhibitors: A safety analysis of the FDA Adverse Event Reporting SystemSemantic proximity Read

Upadacitinib: Mechanism of action, clinical, and translational scienceSemantic proximity Read

Pharmacovigilance analysis of inclisiran:a real-world assessment based on the FAERS databaseSemantic proximity Read

Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors Induced Neurocognitive Disorder: A Pharmacovigilance Study by Analyzing the Data from the U.S. FDA Adverse Event Reporting SystemSemantic proximity Read