Comprehensive Transcriptome Analysis of Patients With Keratoconus Highlights the Regulation of Immune Responses and Inflammatory Processes

Abstract excerpt

Keratoconus (KTCN), characterized by the steeper curvature of the cornea and the thinner central corneal thickness, was a degenerative corneal ectasia with ambiguous etiology and mechanism. We aim to reveal underlying pathological mechanisms of KTCN by multi-level transcriptomic, integrative omics analyses. We performed RNA-sequencing on corneal epithelial samples from seven patients and seven control donors, as...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Corneal surgery and disorders
• Share to Corneal Surgery and Treatments
• Share to Ocular Surface and Contact Lens