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Article

Integrated multi-omics analysis combined with clinical validation reveals that HLA-DRB5 and ODAPH are causal risk genes for keratoconus.

Scientific reports - 10 Mar 2026

Zhao Fanru, Zhao Boyue, Cao Ruiqi, Zhao Wenxin, Zhang Ming, Sun Yishan, Zhao Xinyi, Li Yufan, Hong Yijie, Dang YuFei, Wang Xin, Li Li

Abstract excerpt

This study aimed to elucidate the genetic determinants of keratoconus (KC) using a multi-omics approach, with a focus on identifying key causal genes to address gaps in understanding the disease’s pathological mechanisms. An integrated multi-omics study combining bioinformatics analysis of transcriptome data with clinical validation. This approach does not include a traditional control group but utilizes public...

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Identifiers

PMID: 41803193
DOI: 10.1038/s41598-026-41037-w
PMCID: PMC13179358

Genes

ODAPH
TNF

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