Article

Deciphering and verifying cuproptosis-associated hub genes in diabetic foot ulcer by combining single-cell and bulk RNA-sequencing

2026-04-07

Abstract excerpt

<title>Abstract</title> <p> Prior studies have indicated elevated plasma copper levels in patients with diabetes compared with healthy controls. However, cuproptosis remains unexplored in diabetic foot ulcers (DFUs). DFU-associated datasets (GSE165816, GSE80178, and GSE134431) were obtained from the Gene Expression Omnibus (GEO) database. Cuproptosis-associated genes (CRGs) were identified by combining single-ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1340352b-49d0-5955-8b7a-3202e5ef11f8
DOI: 10.21203/rs.3.rs-5336506/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deciphering and verifying cuproptosis-associated hub genes in diabetic foot ulcer by combining single-cell and bulk RNA-sequencingDOI 10.21203/rs.3.rs-5336506/v1Read

Single-cell RNA sequencing and transcriptomic analysis reveal the critical signatures involved in nonhealing diabetic foot ulcersSemantic proximity Read

Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing dataSemantic proximity Read

Characterization of the microenvironment of diabetic foot ulcers and potential drug identification based on scRNA-seqSemantic proximity Read

Healing mechanism of diabetic foot ulcers using single-cell RNA-sequencingSemantic proximity Read

Single cell transcriptomic landscape of diabetic foot ulcersSemantic proximity Read

Single Cell Transcriptomic Landscape of Diabetic Foot UlcersSemantic proximity Read

Integrating bioinformatics and multiple machine learning to identify mitophagy-related targets for the diagnosis and treatment of diabetic foot ulcers: evidence from transcriptome analysis and drug dockingSemantic proximity Read

Identification of SASP-associated biomarkers and regulatory mechanisms in diabetic foot ulcers based on transcriptomics and experimental validationSemantic proximity Read

Machine learning-driven discovery of novel therapeutic targets in diabetic foot ulcersSemantic proximity Read

Identification and prediction of biomarkers, immune infiltration features, molecular regulatory mechanisms, and potential therapeutic agents associated with cuproptosis in osteoarthritic cartilageSemantic proximity Read

Bioinformatic Analysis Reveals Hub Immune-Related Genes of Diabetic Foot UlcersSemantic proximity Read

Role of M1 macrophages in diabetic foot ulcers and related immune regulatory mechanismsSemantic proximity Read