Article

Restoration of the Lost Human Beta Defensin (hBD-1) in Cancer as a Strategy to Improve the Efficacy of Chemotherapy

2023-04-05

Abstract excerpt

Both innate and adaptive immunity are the important components of the human defense system against various diseases including cancer. Human Beta Defensin (hBD-1) is one such immunomodulatory peptide which is lost at high frequencies in malignant cancers, while high levels of expression are maintained in benign regions making it a potential biomarker for the onset and metastasis of the disease. Loss of putative fun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 24a10dd4-7a25-5526-8793-0f37d69f8392
DOI: 10.1101/2023.04.03.535411

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Restoration of the Lost Human Beta Defensin (hBD-1) in Cancer as a Strategy to Improve the Efficacy of ChemotherapyDOI 10.1101/2023.04.03.535411Read

Human beta-defensin 1: a restless warrior against allergies, infections and cancer.Semantic proximity Read

[Immunological aspects of anticancer chemotherapy].Semantic proximity Read

Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancerSemantic proximity Read

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New PerspectivesSemantic proximity Read

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor controlSemantic proximity Read

DDX58 deficiency leads to doxorubicin chemotherapy resistance by hindering Type I IFN signalling-mediated apoptosis in TNBCSemantic proximity Read

Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cellsSemantic proximity Read

Antimicrobial peptide moricin induces ROS mediated caspase-dependent apoptosis in human triple-negative breast cancer via suppression of notch pathwaySemantic proximity Read

SCFβTrCP-mediated degradation of SHARP1 in triple-negative breast cancer.Semantic proximity Read

Antimicrobial peptide moricin induces ROS mediated caspase-dependent apoptosis in human triple negative breast cancer via suppression of notch pathwaySemantic proximity Read

PAX2 oncogene negatively regulates the expression of the host defense peptide human beta defensin-1 in prostate cancer.Semantic proximity Read

αNAC inhibition of the FADD-JNK axis plays anti-apoptotic role in multiple cancer cells.Semantic proximity Read