Article

DDX58 deficiency leads to doxorubicin chemotherapy resistance by hindering Type I IFN signalling-mediated apoptosis in TNBC

2022-10-17

Abstract excerpt

Triple-negative breast cancer (TNBC) lacks therapeutic targets for precision treatment, making cytotoxic chemotherapy still the primary treatment, but drug resistance often occurs. Unveiling mechanisms for TNBC chemoresistance and trying to reverse this process would undoubtedly improve the overall outcomes. Through three GEO datasets, we found that DDX58 gene was associated with pathological Complete Response (pC...

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Literature Corpus work: 9716ea75-f891-5cdb-b42e-f87fa96adcda
DOI: 10.21203/rs.3.rs-2108631/v1

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