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Article

Human beta-defensin 1: a restless warrior against allergies, infections and cancer.

The international journal of biochemistry & cell biology - 1 Jun 2010

Prado-Montes de Oca Ernesto

Abstract excerpt

Human beta-defensin 1 (hBD-1) is probably the most important antimicrobial peptide in epithelial tissues. Its alleles and/or altered gene expression have been associated with at least 20 human diseases. hBD-1 is a tumor suppressor and DEFB1 is the only innate immunity gene that shows long-term balanced selection and heterozygote advantage. It is unique in its constitutive expression, but is still capable of...

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Anti-Infective Agents
beta-Defensins
Epithelium
Genes, Tumor Suppressor
Hypersensitivity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunity, Innate

Immunomodulation

Source

Identifiers

PMID: 20100591
DOI: 10.1016/j.biocel.2010.01.021

Genes

DEFB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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