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Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

5 Sept 2019

Abstract excerpt

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic target of DNA damaging agents. In this study, we found that inhibition of the class I histone deacetylases (HDAC) exhibited synthetic lethality with BRCA1...

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Identifiers

PMID: 32322466
DOI: 10.1016/j.apsb.2019.08.008

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