Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

doi:10.3390/ijms19113480

Article

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

6 Nov 2018

Abstract excerpt

Mammalian DNA topoisomerases II are targets of anticancer anthracyclines that act by stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to the protein. This molecular mechanism is the molecular basis of anthracycline anticancer activity as well as the toxic effects such as cardiomyopathy and induction of secondary cancers. Even though anthracyclines have been used in the clinic for...

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